Two sample MR report

Telomere_length against aparc-pial rh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0746899	0.1159047	0.5262879
Weighted median	23	0.0098374	0.0599627	0.8696844
Inverse variance weighted	23	-0.0006784	0.0447742	0.9879119
Simple mode	23	-0.1023677	0.1146865	0.3817380
Weighted mode	23	-0.1050431	0.0877578	0.2440590

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.55000	21	0.1252308
Inverse variance weighted	29.22847	22	0.1384527

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046276	0.0065507	0.487684

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008857	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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