Two sample MR report

Telomere_length against aparc-pial rh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0216042	0.1228972	0.8621426
Weighted median	23	0.0235217	0.0569747	0.6797205
Inverse variance weighted	23	0.0252453	0.0471118	0.5920562
Simple mode	23	-0.0092197	0.0871575	0.9167136
Weighted mode	23	0.0183383	0.0624961	0.7719425

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.09764	21	0.0572308
Inverse variance weighted	32.35978	22	0.0714657

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028765	0.0069459	0.6829729

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009933	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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