Two sample MR report

Telomere_length against aparc-pial rh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0040807	0.1293089	0.9751230
Weighted median	23	0.0405250	0.0565141	0.4733261
Inverse variance weighted	23	0.0092334	0.0493832	0.8516803
Simple mode	23	0.0008823	0.1015984	0.9931493
Weighted mode	23	0.0566350	0.0610969	0.3640004

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.53510	21	0.0246431
Inverse variance weighted	35.55627	22	0.0338595

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008175	0.0073083	0.9119987

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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