Two sample MR report

Telomere_length against aparc-pial rh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0086365	0.1122378	0.9393928
Weighted median	23	0.0046102	0.0621474	0.9408657
Inverse variance weighted	23	-0.0376777	0.0429325	0.3801590
Simple mode	23	-0.0308760	0.1148142	0.7904961
Weighted mode	23	0.0282935	0.1022337	0.7845535

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.77325	21	0.1784851
Inverse variance weighted	26.87399	22	0.2160515

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017832	0.0063435	0.781386

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008428	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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