Two sample MR report

Telomere_length against aparc-pial rh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0007337	0.1263850	0.9954230
Weighted median	23	-0.0458751	0.0556520	0.4097574
Inverse variance weighted	23	-0.0361744	0.0483588	0.4544353
Simple mode	23	0.0958419	0.0965435	0.3316341
Weighted mode	23	-0.0301278	0.0626956	0.6355867

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.94562	21	0.0367279
Inverse variance weighted	34.09564	22	0.0480352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002176	0.0071429	0.7636379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010594	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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