Two sample MR report

Telomere_length against aparc-pial rh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0250585	0.1038682	0.8116990
Weighted median	23	0.0018155	0.0542498	0.9733033
Inverse variance weighted	23	-0.0316998	0.0399872	0.4279246
Simple mode	23	0.0001646	0.0833852	0.9984429
Weighted mode	23	-0.0289861	0.0588142	0.6270070

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.92764	21	0.3478488
Inverse variance weighted	23.31240	22	0.3842727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.003485	0.0058704	0.559088

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007266	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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