Two sample MR report

Telomere_length against aparc-pial rh area frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1345330	0.1209482	0.2785729
Weighted median	23	-0.0361720	0.0611981	0.5544770
Inverse variance weighted	23	-0.0161988	0.0481503	0.7365529
Simple mode	23	-0.0973157	0.1122999	0.3955309
Weighted mode	23	-0.0080441	0.0739826	0.9144028

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.08795	21	0.0722066
Inverse variance weighted	33.80158	22	0.0514532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009255	0.0068358	0.1901588

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010295	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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