Two sample MR report

Telomere_length against aparc-pial rh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1236483	0.1037389	0.2465895
Weighted median	23	0.0392481	0.0572521	0.4930083
Inverse variance weighted	23	0.0539192	0.0401064	0.1788181
Simple mode	23	0.0516620	0.0916601	0.5787094
Weighted mode	23	0.0442660	0.0605701	0.4725997

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.87078	21	0.3509066
Inverse variance weighted	23.45151	22	0.3766215

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0042814	0.0058631	0.473322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000769	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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