Two sample MR report

Telomere_length against aparc-pial rh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0831956	0.1343615	0.5424493
Weighted median	23	0.0745201	0.0657488	0.2570437
Inverse variance weighted	23	0.0168061	0.0516494	0.7448870
Simple mode	23	0.0859024	0.1408289	0.5481264
Weighted mode	23	0.1654773	0.1104100	0.1481509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.36911	21	0.0116628
Inverse variance weighted	38.89558	22	0.0145056

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040764	0.0075939	0.5970511

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011842	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8