Two sample MR report

Telomere_length against aparc-pial rh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1563559	0.1149380	0.1881436
Weighted median	23	-0.1024970	0.0542285	0.0587452
Inverse variance weighted	23	-0.0899350	0.0442922	0.0423064
Simple mode	23	-0.1537666	0.0851244	0.0845599
Weighted mode	23	-0.1117939	0.0653994	0.1014465

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.07555	21	0.1380217
Inverse variance weighted	28.60248	22	0.1565638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040782	0.006496	0.5369001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010291	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8