Two sample MR report

Telomere_length against aparc-pial rh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0331415	0.1155262	0.7770199
Weighted median	23	-0.0711273	0.0563370	0.2067571
Inverse variance weighted	23	-0.0192501	0.0443613	0.6643329
Simple mode	23	-0.0908717	0.0997667	0.3722512
Weighted mode	23	-0.0506513	0.0655306	0.4477828

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.36259	21	0.1301644
Inverse variance weighted	28.69042	22	0.1539135

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032168	0.0065293	0.6273512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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