Two sample MR report

Telomere_length against aparc-pial rh area bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1319856	0.0994057	0.1985148
Weighted median	23	-0.0218586	0.0590174	0.7111031
Inverse variance weighted	23	-0.0113274	0.0388453	0.7705896
Simple mode	23	0.0439668	0.1006162	0.6663883
Weighted mode	23	-0.0091611	0.0734007	0.9018081

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.03440	21	0.7090189
Inverse variance weighted	18.77323	22	0.6592870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0074084	0.0056182	0.2014885

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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