Two sample MR report

Telomere_length against aparc-pial rh area TotalSurface

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0888214	0.1306653	0.5040796
Weighted median	23	-0.1215541	0.0683580	0.0753714
Inverse variance weighted	23	-0.0700721	0.0499154	0.1603732
Simple mode	23	-0.2406659	0.1436466	0.1080121
Weighted mode	23	-0.1843010	0.0865533	0.0446616

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.28487	21	0.0203074
Inverse variance weighted	36.32686	22	0.0280044

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011512	0.0073849	0.8776115

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011994	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8