Two sample MR report

Telomere_length against aparc-pial lh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1568767	0.0994057	0.1294779
Weighted median	23	-0.0905779	0.0567749	0.1106255
Inverse variance weighted	23	-0.0710864	0.0388452	0.0672510
Simple mode	23	0.0860557	0.0978491	0.3886502
Weighted mode	23	-0.1196079	0.0634442	0.0726735

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.70398	21	0.6041229
Inverse variance weighted	19.58304	22	0.6091035

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052675	0.0056182	0.3591179

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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