Two sample MR report

Telomere_length against aparc-pial lh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0078275	0.0994060	0.9379829
Weighted median	23	-0.0647817	0.0542678	0.2325789
Inverse variance weighted	23	-0.0805311	0.0388452	0.0381605
Simple mode	23	-0.0483171	0.0920916	0.6050642
Weighted mode	23	-0.0660263	0.0616100	0.2954793

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.92596	21	0.5259551
Inverse variance weighted	20.85844	22	0.5295012

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054252	0.0056182	0.3452106

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007623	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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