Two sample MR report

Telomere_length against aparc-pial lh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0453753	0.1153056	0.6979010
Weighted median	23	-0.0746503	0.0594894	0.2095333
Inverse variance weighted	23	-0.0428721	0.0447414	0.3379512
Simple mode	23	-0.0445305	0.1172037	0.7076325
Weighted mode	23	-0.0772701	0.0934428	0.4171594

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.25570	21	0.1330471
Inverse variance weighted	29.18586	22	0.1396305

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054184	0.0065168	0.4150758

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009213	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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