Two sample MR report

Telomere_length against aparc-pial lh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0364814	0.1057946	0.7336501
Weighted median	23	-0.0215844	0.0644618	0.7377452
Inverse variance weighted	23	-0.0122014	0.0404508	0.7629295
Simple mode	23	0.0563680	0.1132765	0.6236929
Weighted mode	23	-0.0045787	0.1014947	0.9644241

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.78618	21	0.3035338
Inverse variance weighted	23.85659	22	0.3547915

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014908	0.0059793	0.8055315

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007259	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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