Two sample MR report

Telomere_length against aparc-pial lh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0653266	0.1313922	0.6242220
Weighted median	23	-0.1022505	0.0606313	0.0917132
Inverse variance weighted	23	-0.0949201	0.0502354	0.0588238
Simple mode	23	-0.1838456	0.1125967	0.1167472
Weighted mode	23	-0.1001218	0.0718862	0.1776025

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.68969	21	0.0182681
Inverse variance weighted	36.79430	22	0.0249148

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001817	0.007426	0.8090747

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012958	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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