Two sample MR report

Telomere_length against aparc-pial lh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0825805	0.1232814	0.5102504
Weighted median	23	-0.1874656	0.0606767	0.0020044
Inverse variance weighted	23	-0.1118696	0.0471425	0.0176439
Simple mode	23	-0.1632427	0.1195031	0.1857378
Weighted mode	23	-0.1778872	0.0843604	0.0465889

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.30077	21	0.0545688
Inverse variance weighted	32.40324	22	0.0707765

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017984	0.0069676	0.7988403

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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