Two sample MR report

Telomere_length against aparc-pial lh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0502050	0.1244012	0.6906065
Weighted median	23	-0.1263247	0.0592588	0.0330279
Inverse variance weighted	23	-0.0614357	0.0475062	0.1959370
Simple mode	23	-0.1290092	0.1098854	0.2529343
Weighted mode	23	-0.1355260	0.0733452	0.0781243

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.88922	21	0.0474601
Inverse variance weighted	32.90428	22	0.0632330

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006896	0.0070309	0.9228018

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010728	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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