Two sample MR report

Telomere_length against aparc-pial lh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1467796	0.1340297	0.2858624
Weighted median	23	-0.0344025	0.0656772	0.6004092
Inverse variance weighted	23	-0.0030527	0.0527985	0.9538932
Simple mode	23	-0.2001932	0.1211249	0.1125764
Weighted mode	23	-0.0444137	0.0879511	0.6185927

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.17715	21	0.0122861
Inverse variance weighted	40.64446	22	0.0090814

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0088248	0.007575	0.2570899

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012317	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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