Two sample MR report

Telomere_length against aparc-pial lh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1240411	0.0994055	0.2258290
Weighted median	23	-0.1067908	0.0568366	0.0602569
Inverse variance weighted	23	-0.0778073	0.0388452	0.0451764
Simple mode	23	-0.1600435	0.0966121	0.1118036
Weighted mode	23	-0.1184743	0.0667691	0.0898402

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.27979	21	0.5036059
Inverse variance weighted	20.53510	22	0.5496058

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028387	0.0056182	0.6186245

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007439	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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