Two sample MR report

Telomere_length against aparc-pial lh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0337130	0.1216505	0.7843901
Weighted median	23	-0.0572649	0.0586782	0.3291070
Inverse variance weighted	23	-0.0525544	0.0464767	0.2581519
Simple mode	23	-0.0185485	0.0961375	0.8487783
Weighted mode	23	-0.0486206	0.0733927	0.5145493

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.45006	21	0.0664870
Inverse variance weighted	31.49246	22	0.0864701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011569	0.0068754	0.8679882

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010097	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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