Two sample MR report

Telomere_length against aparc-pial lh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1414316	0.1137996	0.2276353
Weighted median	23	-0.0591161	0.0584486	0.3118153
Inverse variance weighted	23	-0.0356246	0.0444906	0.4232920
Simple mode	23	-0.0858918	0.1060893	0.4268303
Weighted mode	23	-0.0894374	0.0695142	0.2116062

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.52225	21	0.1542281
Inverse variance weighted	28.85939	22	0.1489193

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0064965	0.0064317	0.3239538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	9e-04	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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