Two sample MR report

Telomere_length against aparc-pial lh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0162914	0.1286295	0.9004195
Weighted median	23	0.0341882	0.0645861	0.5965673
Inverse variance weighted	23	0.0266363	0.0491189	0.5876238
Simple mode	23	0.0165948	0.1196547	0.8909575
Weighted mode	23	0.0123482	0.1012082	0.9040000

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.16410	21	0.0270861
Inverse variance weighted	35.17688	22	0.0371274

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006352	0.0072699	0.9312038

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010801	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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