Two sample MR report

Telomere_length against aparc-pial lh area parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1526726	0.0994047	0.1395011
Weighted median	23	-0.0877170	0.0593973	0.1397332
Inverse variance weighted	23	-0.0722015	0.0388449	0.0630679
Simple mode	23	-0.0304928	0.1101336	0.7844639
Weighted mode	23	-0.0623232	0.0794800	0.4413211

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.23730	21	0.6339416
Inverse variance weighted	19.01075	22	0.6446646

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.004941	0.0056182	0.3891057

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006807	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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