Two sample MR report

Telomere_length against aparc-pial lh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0761807	0.1572730	0.6331262
Weighted median	23	0.0492083	0.0604601	0.4157042
Inverse variance weighted	23	0.0280487	0.0607819	0.6444648
Simple mode	23	0.1391028	0.1305186	0.2980850
Weighted mode	23	-0.0942360	0.0871930	0.2915029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.56580	21	0.0001587
Inverse variance weighted	53.86334	22	0.0001719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0063997	0.0088887	0.4794763

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016476	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8