Two sample MR report

Telomere_length against aparc-pial lh area parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1985536	0.0994045	0.0588984
Weighted median	23	-0.0616784	0.0583057	0.2901263
Inverse variance weighted	23	-0.0382467	0.0397998	0.3365626
Simple mode	23	0.0593318	0.1183361	0.6210813
Weighted mode	23	-0.1227269	0.0949446	0.2095555

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.02556	21	0.5196429
Inverse variance weighted	23.09499	22	0.3963828

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0098429	0.0056182	0.0943693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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