Two sample MR report

Telomere_length against aparc-pial lh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0327733	0.0999547	0.7462479
Weighted median	23	0.0278014	0.0568341	0.6247223
Inverse variance weighted	23	0.0107691	0.0388452	0.7816028
Simple mode	23	0.1017116	0.1190299	0.4020353
Weighted mode	23	-0.0899425	0.0715424	0.2218678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.23267	21	0.4448157
Inverse variance weighted	21.45912	22	0.4925399

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026735	0.0056492	0.6409163

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006526	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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