Two sample MR report

Telomere_length against aparc-pial lh area paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0540005	0.0999301	0.5946183
Weighted median	23	-0.0508344	0.0595673	0.3934402
Inverse variance weighted	23	-0.0267721	0.0388449	0.4906942
Simple mode	23	-0.0351903	0.1217510	0.7752605
Weighted mode	23	-0.1389125	0.0943519	0.1551077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.22280	21	0.4454116
Inverse variance weighted	21.31136	22	0.5015736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0016718	0.0056479	0.7701284

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006602	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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