Two sample MR report

Telomere_length against aparc-pial lh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1079986	0.0994059	0.2895981
Weighted median	23	-0.0079194	0.0556666	0.8868708
Inverse variance weighted	23	0.0329303	0.0388453	0.3965888
Simple mode	23	0.1011668	0.1091615	0.3641060
Weighted mode	23	-0.0874649	0.0655186	0.1955397

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.24203	21	0.6963340
Inverse variance weighted	19.61418	22	0.6071597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086531	0.0056182	0.1384512

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006161	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8