Two sample MR report

Telomere_length against aparc-pial lh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1859487	0.1308279	0.1699039
Weighted median	23	0.0462374	0.0571821	0.4187450
Inverse variance weighted	23	-0.0091618	0.0529784	0.8627031
Simple mode	23	-0.1558568	0.1030396	0.1446170
Weighted mode	23	0.0575930	0.0618278	0.3617017

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.37473	21	0.0198376
Inverse variance weighted	40.92152	22	0.0084201

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0119797	0.0073941	0.1201149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012416	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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