Two sample MR report

Telomere_length against aparc-pial lh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0270501	0.0994053	0.7881875
Weighted median	23	0.0559467	0.0575681	0.3311324
Inverse variance weighted	23	0.0022362	0.0388453	0.9540938
Simple mode	23	0.0493233	0.1052000	0.6437875
Weighted mode	23	0.0761726	0.0812561	0.3587110

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.95613	21	0.5879546
Inverse variance weighted	19.05857	22	0.6417090

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017982	0.0056182	0.7520816

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005776	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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