Two sample MR report

Telomere_length against aparc-pial lh area lateralorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0449888	0.1342246	0.7408178
Weighted median	23	0.0458927	0.0618878	0.4583617
Inverse variance weighted	23	-0.0159907	0.0513127	0.7553200
Simple mode	23	0.1365465	0.1343647	0.3205627
Weighted mode	23	0.0640113	0.0813648	0.4398390

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.28736	21	0.0119246
Inverse variance weighted	38.38779	22	0.0165684

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017805	0.0075861	0.8167121

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011683	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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