Two sample MR report

Telomere_length against aparc-pial lh area lateraloccipital

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0209450	0.1486256	0.8892726
Weighted median	23	-0.0313940	0.0616245	0.6104432
Inverse variance weighted	23	0.0457009	0.0567879	0.4209557
Simple mode	23	0.1205146	0.1208738	0.3295916
Weighted mode	23	-0.0080859	0.0829879	0.9232637

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.94594	21	0.0009550
Inverse variance weighted	47.01914	22	0.0014592

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00152	0.0084	0.8581391

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014666	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8