Two sample MR report

Telomere_length against aparc-pial lh area isthmuscingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1624196	0.1112060	0.1589454
Weighted median	23	-0.0060914	0.0557692	0.9130234
Inverse variance weighted	23	-0.0099310	0.0446441	0.8239643
Simple mode	23	-0.0909038	0.0987275	0.3671656
Weighted mode	23	-0.0099679	0.0594275	0.8683259

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.28061	21	0.1959509
Inverse variance weighted	29.05776	22	0.1432192

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0093627	0.0062851	0.1511765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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