Two sample MR report

Telomere_length against aparc-pial lh area inferiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1189128	0.1080478	0.2835450
Weighted median	23	-0.0549781	0.0607035	0.3651037
Inverse variance weighted	23	-0.0565335	0.0416368	0.1745341
Simple mode	23	-0.0564358	0.1178987	0.6368893
Weighted mode	23	-0.0310524	0.1003481	0.7598937

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.81187	21	0.2554041
Inverse variance weighted	25.27666	22	0.2840283

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0038301	0.0061067	0.537286

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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