Two sample MR report

Telomere_length against aparc-pial lh area inferiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0894970	0.1176717	0.4553724
Weighted median	23	0.0325963	0.0573525	0.5697965
Inverse variance weighted	23	0.0482450	0.0466232	0.3007696
Simple mode	23	-0.0115378	0.1041878	0.9128263
Weighted mode	23	0.0235406	0.0602257	0.6996505

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.42626	21	0.1041382
Inverse variance weighted	31.69230	22	0.0827955

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0084573	0.0066505	0.2173927

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001007	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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