Two sample MR report

Telomere_length against aparc-pial lh area fusiform

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0167429	0.1134801	0.8841128
Weighted median	23	-0.0386016	0.0588917	0.5121671
Inverse variance weighted	23	-0.0615027	0.0439006	0.1612277
Simple mode	23	-0.0943974	0.0985005	0.3483034
Weighted mode	23	-0.0557491	0.0719414	0.4466349

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.36764	21	0.1590131
Inverse variance weighted	28.09889	22	0.1724271

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048042	0.0064136	0.4621233

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009274	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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