Two sample MR report

Telomere_length against aparc-pial lh area frontalpole

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0004863	0.1180378	0.9967518
Weighted median	23	0.0136919	0.0567367	0.8093041
Inverse variance weighted	23	-0.0114511	0.0450762	0.7994657
Simple mode	23	-0.1192529	0.1012265	0.2513517
Weighted mode	23	0.0125618	0.0640502	0.8463138

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.60888	21	0.1001339
Inverse variance weighted	29.62324	22	0.1279128

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006732	0.0066712	0.9205741

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009003	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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