Two sample MR report

Telomere_length against aparc-pial lh area entorhinal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0426533	0.1438630	0.7697719
Weighted median	23	-0.0208100	0.0584604	0.7218650
Inverse variance weighted	23	-0.0254213	0.0552701	0.6455540
Simple mode	23	-0.0787198	0.1074153	0.4713843
Weighted mode	23	-0.0244914	0.0597260	0.6857260

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.98279	21	0.0023502
Inverse variance weighted	44.53627	22	0.0030374

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041798	0.0081308	0.6125732

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013625	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8