Two sample MR report

Telomere_length against aparc-pial lh area cuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0261437	0.1464605	0.8600387
Weighted median	23	-0.0897479	0.0612168	0.1426301
Inverse variance weighted	23	0.0026243	0.0559784	0.9626091
Simple mode	23	-0.1825471	0.1161151	0.1301945
Weighted mode	23	-0.1100226	0.0874875	0.2217293

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.58895	21	0.0014487
Inverse variance weighted	45.68780	22	0.0021687

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017663	0.0082776	0.8330818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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