Two sample MR report

Telomere_length against aparc-pial lh area caudalmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0969450	0.1025546	0.3552553
Weighted median	23	-0.0970701	0.0560590	0.0833501
Inverse variance weighted	23	-0.1011188	0.0391559	0.0098097
Simple mode	23	-0.0708986	0.0956135	0.4662248
Weighted mode	23	-0.0771798	0.0630470	0.2338387

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.35131	21	0.3795137
Inverse variance weighted	22.35339	22	0.4389727

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002563	0.0057961	0.9651513

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008827	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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