Two sample MR report

Telomere_length against aparc-pial lh area caudalanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0694018	0.0994065	0.4927355
Weighted median	23	-0.0506320	0.0559274	0.3652978
Inverse variance weighted	23	-0.0026735	0.0388456	0.9451299
Simple mode	23	-0.1098344	0.1011742	0.2894105
Weighted mode	23	-0.0726407	0.0850115	0.4020477

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.25778	21	0.6326379
Inverse variance weighted	18.87823	22	0.6528352

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044254	0.0056182	0.43968

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005722	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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