Two sample MR report

Telomere_length against aparc-pial lh area bankssts

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0368974	0.1150544	0.7516105
Weighted median	23	-0.0758133	0.0590150	0.1989166
Inverse variance weighted	23	-0.0593795	0.0447824	0.1848542
Simple mode	23	-0.0619439	0.1074200	0.5700290
Weighted mode	23	-0.0478432	0.0764923	0.5381008

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.1322	21	0.1364417
Inverse variance weighted	29.2393	22	0.1381547

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059114	0.0065026	0.3736248

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009568	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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