Two sample MR report

Telomere_length against aparc-pial lh area TotalSurface

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1501640	0.1377305	0.2879450
Weighted median	23	-0.1174208	0.0662819	0.0764713
Inverse variance weighted	23	-0.0780220	0.0529878	0.1408988
Simple mode	23	0.1163166	0.1481666	0.4408032
Weighted mode	23	-0.1655229	0.1139768	0.1605457

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.31567	21	0.0068060
Inverse variance weighted	40.93730	22	0.0083838

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0044296	0.0077843	0.5753672

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013627	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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