Two sample MR report

Telomere_length against aparc-a2009s rh volume S-temporal-transverse

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.3034836	0.1069955	0.0098869
Weighted median	23	-0.0484201	0.0579533	0.4034356
Inverse variance weighted	23	-0.0199223	0.0482435	0.6796407
Simple mode	23	-0.0633792	0.1089773	0.5667602
Weighted mode	23	-0.0771987	0.0754090	0.3170870

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.32851	21	0.2774151
Inverse variance weighted	33.93192	22	0.0499127

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0174107	0.0060472	0.0089784

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010362	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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