Two sample MR report

Telomere_length against aparc-a2009s rh volume S-temporal-sup

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1068368	0.1285246	0.4151815
Weighted median	23	-0.0635685	0.0580772	0.2737125
Inverse variance weighted	23	-0.0730404	0.0491647	0.1373778
Simple mode	23	-0.1305634	0.1002287	0.2061646
Weighted mode	23	-0.0913967	0.0671663	0.1873704

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.10586	21	0.0274890
Inverse variance weighted	35.24229	22	0.0365447

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020751	0.0072639	0.7779287

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001175	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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