Two sample MR report

Telomere_length against aparc-a2009s rh volume S-temporal-inf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0938431	0.1007895	0.3623935
Weighted median	23	0.0014057	0.0617274	0.9818312
Inverse variance weighted	23	-0.0228030	0.0390145	0.5589009
Simple mode	23	0.1703740	0.1237111	0.1823049
Weighted mode	23	0.0095369	0.1011901	0.9257660

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.58975	21	0.4234715
Inverse variance weighted	22.19255	22	0.4484472

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043619	0.0056965	0.4523622

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006829	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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