Two sample MR report

Telomere_length against aparc-a2009s rh volume S-subparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2763381	0.1237198	0.0365194
Weighted median	23	-0.0481703	0.0579949	0.4062020
Inverse variance weighted	23	0.0004579	0.0534680	0.9931674
Simple mode	23	-0.1355088	0.0840842	0.1213074
Weighted mode	23	-0.0953099	0.0617510	0.1369841

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.52998	21	0.0516957
Inverse variance weighted	41.68104	22	0.0068306

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.016995	0.0069923	0.0241241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012629	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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